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The Garfield and Dr Seuss, Sonic Generations, The ZhuZhus' Cindy-Lou Who and Frankie Pamplemousse Show Theme is an instrumental piece of music used as for the opening and ending sequences of The Garfield and Dr Seuss, Sonic Generations, The ZhuZhus' Cindy-Lou Who and Frankie Pamplemousse Show. It is also heard as background music in multiple episodes of the series.

The music has an R&B-flavored sound, with a horn section prominently played as well as saxophone and electric guitar as the lead instruments. Sound effects and Garfield and Cindy-Lou Who and Frankie's voice are also heard at the beginning and end of the opening sequence.